William R Wilcox Selected Research

Achondroplasia

1/2022	Pharmacokinetics and Exposure-Response of Vosoritide in Children with Achondroplasia.
12/2021	Safe and persistent growth-promoting effects of vosoritide in children with achondroplasia: 2-year results from an open-label, phase 3 extension study.
4/2015	Neutral endopeptidase-resistant C-type natriuretic peptide variant represents a new therapeutic approach for treatment of fibroblast growth factor receptor 3-related dwarfism.
11/2014	FGFR3 mutation frequency in 324 cases from the International Skeletal Dysplasia Registry.
1/2012	Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias.
11/2005	Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis.

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William R Wilcox Research Topics

Disease

23	Fabry Disease (Fabry's Disease) 12/2020 - 02/2003
6	Achondroplasia 01/2022 - 11/2005
5	Neoplasms (Cancer) 03/2016 - 08/2007
4	Chondrosarcoma 08/2007 - 11/2005
3	Inborn Genetic Diseases (Disease, Hereditary) 05/2015 - 08/2006
3	Dwarfism 04/2015 - 07/2010
3	Multiple Myeloma 01/2014 - 06/2009
2	Diarrhea 12/2020 - 01/2018
2	Abdominal Pain (Pain, Abdominal) 12/2020 - 01/2018
2	Stroke (Strokes) 01/2016 - 05/2015
2	Proteinuria 01/2007 - 08/2003
1	Infections 12/2020
1	COVID-19 12/2020
1	X-Linked Genetic Diseases 01/2020
1	Respiratory Insufficiency (Respiratory Failure) 01/2019
1	Congenital Abnormalities (Deformity) 01/2019
1	Failure to Thrive 01/2019
1	Hypophosphatasia 01/2019
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2016
1	Hypotension (Low Blood Pressure) 12/2015
1	Schneckenbecken dysplasia 10/2015
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 05/2015
1	Renal Insufficiency (Renal Failure) 05/2015
1	Thanatophoric Dysplasia (Dwarfism, Thanatophoric) 11/2014
1	Polydactyly (Polydactylism) 08/2014
1	Triphalangeal Thumb 08/2014
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2014
1	Fibrochondrogenesis 11/2010
1	Carcinoma (Carcinomatosis) 07/2010
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 05/2010
1	Gerodermia osteodysplastica 12/2008
1	Lymphoid Leukemia 12/2007
1	Body Weight (Weight, Body) 01/2007
1	Pelger-Huet Anomaly 04/2003
1	HEM dysplasia 04/2003
1	Chronic Kidney Failure (Chronic Renal Failure) 02/2003
1	Spinocerebellar Degenerations (Marinesco Sjogren Syndrome) 05/2002

Drug/Important Bio-Agent (IBA)

8	GalactosidasesIBA 01/2020 - 03/2012
7	agalsidase beta FDA Link 12/2020 - 01/2007
7	alpha-Galactosidase (Beano)IBA 05/2010 - 02/2003
6	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 12/2021 - 06/2009
6	GlycosphingolipidsIBA 01/2018 - 08/2006
5	globotriaosylceramide (globotriosylceramide)IBA 12/2015 - 09/2005
4	EnzymesIBA 05/2015 - 09/2005
3	vosoritideIBA 01/2022 - 04/2015
3	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 01/2022 - 04/2015
3	migalastatIBA 01/2017 - 08/2016
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2012 - 07/2010
3	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 12/2007 - 03/2007
2	GlycolipidsIBA 12/2020 - 07/2009
2	LipidsIBA 08/2003 - 05/2002
1	AngiotensinsIBA 12/2020
1	ReninIBA 12/2020
1	CalciumIBA 01/2019
1	Pharmaceutical PreparationsIBA 03/2016
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2015
1	Inositol (Myoinositol)IBA 10/2015
1	PolyphosphatesIBA 10/2015
1	Neprilysin (Neutral Endopeptidase)IBA 04/2015
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 04/2015
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 04/2015
1	Tuberculin (PPD)IBA 08/2014
1	9 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)IBA 08/2014
1	Transcription Factors (Transcription Factor)IBA 01/2014
1	Phosphotransferases (Kinase)IBA 01/2014
1	Tyrosine (L-Tyrosine)FDA Link 01/2014
1	Biological ProductsIBA 01/2014
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 11/2010
1	Collagen Type XIIBA 11/2010
1	ChemokinesIBA 07/2010
1	4,4,',4'',4'''- (carbonylbis(imino- 5,1,3- benzenetriylbis(carbonylimino)))tetrakis(benzene- 1,3- disulfonate)IBA 07/2010
1	VitaminsIBA 06/2010
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 06/2009
1	Golgi Matrix ProteinsIBA 12/2008
1	Proteins (Proteins, Gene)FDA Link 12/2007
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 08/2007
1	Fibroblast Growth Factor 1 (FGF-1)IBA 03/2007
1	bisindolylmaleimide IIBA 02/2007
1	Protein Kinase CIBA 02/2007
1	Mitogen-Activated Protein KinasesIBA 11/2005
1	Natriuretic PeptidesIBA 11/2005
1	CreatinineIBA 08/2003
1	ChromatinIBA 04/2003
1	delta(14)-sterol reductaseIBA 04/2003
1	Lamin B ReceptorIBA 04/2003

Therapy/Procedure

11	Therapeutics 12/2020 - 02/2003
10	Enzyme Replacement Therapy 12/2020 - 02/2003
1	Mechanical Ventilators (Ventilator) 01/2019
1	Precision Medicine 03/2016
1	Renal Dialysis (Hemodialysis) 01/2016
1	Heart Transplantation (Grafting, Heart) 01/2016
1	Intravenous Infusions 01/2007